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Offspring of women with epilepsy who were exposed to antiepileptic drugs had a higher rate of fetal death and anomalies than did the control population(P=.001).Abnormal outcomes were associated with the three major antiepileptic drugs(carbamazepine,phenytoin,and phenobarbital).In terms of abnormal outcome(death and anomalies),phenobarbital was associated with the highest relative risk,phenytoin with intermediate relative risk,and carbamazepine with the lowest relative risk(P=.019).Numbers were insufficient for assessment of risk associated with valproic acid.All three major antiepileptic drugs(phenobarbital,phenytoin,and carbamazepine) are associated with an increased risk of fetal death and anomalies.We found phenobarbital to be most associated with poor pregnancy outcome. |
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